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EXCEDRIN PRODUCTS: INGREDIENTS & DOSAGE 


Learn more about the pain-fighting ingredients in Excedrin ® products, appropriate dosages, and how to choose the best Excedrin product for your needs.e proper usage and dosing for Excedrin® products.

EXCEDRIN: INGREDIENTS & DOSAGE GUIDELINES

Knowing the correct dosage of Excedrin will help you get fast-acting relief for headache pain while lowering the risk of taking too much of the active ingredients (aspirin, acetaminophen, caffeine and diphenhydramine citrate). All Excedrin products should be taken with a full glass of water.

Aspirin Acetaminophen Caffeine
Has been a go-to for all types of pain for decades, including headaches and migraines. Is a powerful ingredient for pain relief, and is tough when fighting headaches. Enhances the pain-relieving function of aspirin and acetaminophen.

ASPIRIN, ACETAMINOPHEN & CAFFEINE:

WORKING TOGETHER

Two of Excedrin’s popular products, Excedrin Extra Strength and Excedrin Migraine, contain three ingredients that work together—acetaminophen, aspirin and caffeine. Combining these ingredients results in two pain relievers plus an amplifier to enhance the analgesic effect. Doctors believe this combination, when taken as directed, can offer major advantages—including reliable headache relief.

Aspirin

Has been a go-to for all types of pain for decades, including headaches and migraines.

Acetaminophen

Is a powerful ingredient for pain relief, and is tough when fighting headaches.

Caffeine

Enhances the pain-relieving function of aspirin and acetaminophen.

Use only as directed. Read all warnings and full product information prior to use. Always follow label directions

HOW THE ACTIVE INGREDIENTS IN EXCEDRIN PRODUCTS WORK TOGETHER TO STOP HEADACHES


Evidence suggests that the use of combination analgesics such as Excedrin offer advantages in the treatment of headaches by targeting pain in more than one way.[3]


Excedrin contains two analgesics (pain relievers) – acetaminophen and aspirin. These two ingredients work with your cells, nerves and brain to help reduce pain. When a part of your body is injured or damaged, your body releases a chemical called ‘prostaglandin’. This is then picked up by the nerves, which transmit pain signals to the brain. Pain relievers like acetaminophen and aspirin block damaged cells from releasing prostaglandin, so your brain does not receive pain signals as clearly or quickly – helping to reduce pain severity.[4,5]


Acetaminophen, aspirin and caffeine, when taken as directed, provide clinically proven headache relief. Excedrin is a combination of these ingredients: two pain relievers, plus an amplifier to enhance the analgesic effect.

 

 

CAFFEINE: A KEY INGREDIENT TO THE EXCEDRIN LIST


You may have heard that caffeine can cause or exacerbate headaches, and if so, you’re probably wondering why there’s caffeine in most Excedrin products.


It’s true that caffeine can be a headache trigger in certain situations, but that’s far from the full story.


Caffeine is referred to as an ‘analgesic adjuvant’. This means that it helps to boost the effects of certain pain relievers. In the case of Excedrin, caffeine boosts the pain-relieving effects of aspirin and acetaminophen – making these medicines up to 40% more effective.[2]


That’s why you’ll find caffeine in almost all Excedrin products. Only Excedrin PM Headache does not contain caffeine, as caffeine consumed too close to bedtime can keep you from getting a good night’s sleep.


 

FIND THE EXCEDRIN PRODUCT THAT'S RIGHT FOR YOU


Excedrin has been a leader in headache relief for more than 50 years, and the range of Excedrin products contains something for every kind of headache, including tension headaches, nighttime headaches and migraines.


Discover the full Excedrin product range here, or, if you need more help finding the right product for you, try our interactive product selector.


Sources:


1. American Migraine Foundation. Understanding Caffeine Headaches. https://americanmigrainefoundation.org/resource-library/understanding-caffeine-headaches/. Accessed November 27, 2019. Referenced text is highlighted in source PDF.


2. Caffeine in the management of patients with headache. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655397/. Accessed 10/12/19.WebMD. The Link Between Caffeine and Headac


3. Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?. Straube et al. BMC Neurologly. https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-43. Accessed 20/03/20


4. How Do Pain Relievers Work? Johns Hopkins Medicine. https://www.hopkinsallchildrens.org/Patients-Families/Health-Library/HealthDocNew/How-Do-Pain-Relievers-Work. Accessed 31/03/20.


5. Aspirin and Migraine. National Headache Foundation. https://headaches.org/2007/10/25/aspirin-and-migraine/. Accessed 31/03/20.

 

 

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