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Excedrin

Excedrin Ingredients & Dosage

Learn more about the pain-fighting ingredients in Excedrin pain relief products, as well as Head Care* ingredients and suggested use.

Ingredients & Dosage Guidelines

Select one to see the ingredients and dosage guidelines. All Excedrin products should be taken with a full glass of water.

  • Excedrin Headache & Migraine Relief: Ingredients & Dosage Guidelines

    Aspirin Acetaminophen Caffeine
    Has been a go-to for all types of pain for decades, including headache and migraines. Is a powerful ingredient for pain relief, and is tough when fighting headaches. Enhances pain-relieving function of aspirin and acetaminophen.

    Use only as directed. Read all warnings and product information prior to use. Always follow label directions

  • Head Care Proactive Health Ingredients & Supplement Facts*

    Magnesium Riboflavin Vitamin B6, Folic Acid, Vitamin B12
    Essential nutrient that helps support blood flow in the brain for head comfort.*† Essential nutrient with antioxidant properties that also helps support brain energy production.* A unique combination of ingredients that help support a healthy neurological system.*

    Read all warnings and product information prior to use. Always follow label directions.

  • Head Care Replenish +Focus Ingredients & Nutrition Facts

    Electrolytes Ginger Caffeine
    Formulated with guidance from the World Health Organization oral rehydration solution (ORS). Science-based ingredient that helps soothe and support the stomach. Helps support focus.

    Read all warnings and product information prior to use. Always follow label directions.

  • Head Care Replenish +Sleep Ingredients & Dietary Supplement Facts*^

    Electrolytes Ginger L-Theanine
    Formulated with guidance from the World Health Organization oral rehydration solution (ORS). Science-based ingredient that helps soothe and support the stomach. Helps support a healthy stress response and promotes relaxation.*^

    Read all warnings and product information prior to use. Always follow label directions.

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How the Active Ingredients in Excedrin Headache & Migraine Relief Work Together to Stop Headaches

Evidence suggests that the use of combination analgesics such as Excedrin offer advantages in the treatment of headaches by targeting pain in more than one way.3

Excedrin’s specialized formula contains two pain relievers (acetaminophen and aspirin) plus an amplifier (caffeine) that work together to target head pain. Aspirin is a non-steroidal anti-inflammatory drug or NSAID. Aspirin helps to block the production of pain signaling chemicals called prostaglandins. The way in which acetaminophen works is still not well understood. However, it is believed to elevate the pain threshold. This allows you to tolerate more pain, therefore providing pain relief. Finally, caffeine has been shown to increase the potency of aspirin and acetaminophen by up to 40 percent. This means less acetaminophen and aspirin is needed to relieve your migraine pain when combined with caffeine.3,4,5

Acetaminophen, aspirin and caffeine, when taken as directed, provide clinically proven headache relief. Excedrin is a combination of these ingredients: two pain relievers, plus an amplifier to enhance the analgesic effect.

Acetaminophen, also known as paracetamol, should not be taken with other medicines that also contain acetaminophen. Acetaminophen is contained in many medicines to treat pain, fever, symptoms of cold and flu, and sleep medicines. Do not take more than recommended dose, as this may be harmful, including serious harm to your liver. If you have liver or kidney disease, talk to your doctor before taking acetaminophen.

- EXTRA STRENGTH MIGRAINE TENSION HEADACHE PM HEADACHE
Contains Acetaminophen

.

(250 mg per tablet)

.

(250 mg per tablet)

.

(500 mg per tablet)

.

(250 mg per tablet)
Contains Aspirin

.

(250 mg per tablet)

.

(250 mg per tablet)

 -

.

(250 mg per tablet)
Contains Caffeine

.

(65 mg per tablet)

.

(65 mg per tablet)

.

(65 mg per tablet)

 -
Contains Diphenhydramine (Sleep Aid) - - -

.

(38 mg per tablet)
Age 12 Years & Older 18 Years & Older 12 Years & Older 12 Years & Older
Dose

.

2 Every 6 Hours (Max 8 Per Day)

.

2 Per Day (Max 2 Per Day)

.

2 Every 6 Hours (Max 6 Per Day)

.

2 Per Day (Max 2 Per Day)
Available in Caplets . . . .
Available in Geltabs . . - -
- Proactive Health* Replenish +Focus Replenish +Sleep*^
Contains Electrolytes - . .
Contains Caffeine - . -
Contains Melatonin     .
Age 18 Years or Older 18 Years or Older 18 Years or Older
Frequency 1 tablet per day Limit 2 packets per day Limit 1 packet per day
Available in Tablets . - -
Available in Powder - . .

Caffeine: A Key Ingredient to The Excedrin List

You may have heard that caffeine can cause or exacerbate headaches, and if so, you’re probably wondering why there’s caffeine in most Excedrin pain relief products.

It’s true that caffeine can be a headache trigger in certain situations, but that’s far from the full story.

Caffeine is referred to as an ‘analgesic adjuvant’. This means that it helps to boost the effects of certain pain relievers. In the case of Excedrin pain relief products, caffeine boosts the pain-relieving effects of aspirin and acetaminophen – making these medicines up to 40% more effective.

That’s why you’ll find caffeine in almost all Excedrin pain relief products. Only Excedrin PM Headache does not contain caffeine, as caffeine consumed too close to bedtime can keep you from getting a good night’s sleep.

Head Care Replenish +Focus also contains caffeine to help support focus.

Head Care products are not intended to treat migraines.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Find the Excedrin Product That's Right For You

Excedrin has been a leader in headache relief for more than 50 years, and the range of Excedrin products contains something for every kind of headache, including tension headaches, nighttime headaches and migraines.

Discover the full Excedrin product range here, or, if you need more help finding the right product for you, try our interactive product selector.