Excedrin® Extra Strength Caplets

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Extra Strength Headache Relief

For some, headache relief starts in just 15 minutes.

Excedrin® Extra Strength Caplets

Use as Directed

Excedrin Extra Strength combines three active ingredients to provide a strong over-the-counter medicine for headaches and other kinds of pain.
It has a fast-acting formula that delivers extra strength headache relief. For some, relief starts in as little as 15 minutes –to help you get back to your day.


Excedrin Extra Strength
temporarily relieves minor aches and pains due to: (1)

  • Headache
  • A Cold
  • Arthritis
  • Muscular Aches      
  • Toothache
  • Premenstrual & Menstrual Cramps


  • Do not take more of this product than directed
  • Drink a full glass of water with each dose
  • Adults and children 12 years and older: two tablets every sixhours not more than eight tablets in any 24hours
  • Children under 12 years: Ask a doctor
Children under 12 years old: Ask a doctor


  • Acetaminophen:
    250 mg/caplet or geltab (pain reliever)
  • Aspirin (NSAID**):
    250 mg/caplet or geltab (pain reliever)
  • Caffeine:
    65 mg/caplet or geltab (pain reliever aid)

*Two tablet dose **Nonsteroidal
anti-inflammatory drug


As with all medicines, Excedrin Extra Strengthis not suitable for everyone and carries the risk of side effects – some of them serious. Please click here for the full product information, and be sure to read it through carefully before taking Excedrin Extra Strength.


How soon will Excedrin Extra Strength relieve my headache?

It can vary from person to person, but generally speaking, Excedrin Extra Strengthis a fast-acting pain reliever. In clinical studies, some patients started to feel relief 15 minutes after taking it.

Can I take other headache pills (strong or otherwise) with Excedrin Extra Strength?

You should ask your doctor or pharmacist before taking any other drug with Excedrin ES. Excedrin ES contains an NSAID (aspirin), which may cause severe stomach bleeding. The chance is higher if you take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others). You shouldn’t use Excedrin ES with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. (1)

I’ve heard that caffeine can cause or exacerbate headaches. Why is there caffeine in Excedrin Extra Strength headache relief pills?

It’s true that caffeine can be a headache trigger in certain situations, but that’s not the full story. In fact, caffeine can actually help relieve headaches (including migraines) when ingested as part of an OTC headache treatment, as it boosts the effects of pain relievers such as aspirin and acetaminophen – making these medicines up to 40% more effective. (2)

What if Excedrin Extra Strength headache relief isn’t right for me?

If Excedrin Extra Strength isn’t quite right for you, don’t worry – one of our other products may be a better fit. Click here for our interactive product selector, which will help you find the product that best meets your needs. Always read and follow the product label.



1. EXCEDRIN EXTRA STRENGTH -Drug Fact Label. National Institutes of Health! 
Accessed 07/01/20.

2. Laska JAMA 1984 251(13); 6 Apr 1711-1718 and Lipton et al. The Journal of Headache and Pain (2017) 18:107
Accessed 07/01/20

Where to Buy Excedrin® Products Near You


Grandpa Ed

Glad you're finally back in production!

I've been relying on Excedrin for over 40 yrs. Two Excedrin at the hint of a headache immediately prevents the inevitable increase of extreme pain that used to occur, while producing a welcome relaxed mood (probably due to the Caffeine). The fact that other products advertise "same ingredients as Excedrin" attests to your leadership in the field of pain relief. I recommend the caplet form of Excedrin for anyone who has difficulty swallowing round pills, as I have developed with aging. Also, your new Excedrin PM has proven to be very effective, replacing Caffeine with a sleep aid so close to bedtime. (I carry Excedrin with me at all times, not only for myself, but for all members of my family).


Only Excedrin

I have used Excedrin most of my life. I am one of the unfortunate people who gets a lot of headaches. Once I discovered Excedrin, I have never used anything else. I have, over the years, brought many, many people to the wonderful world of Excedrin. All who have switched say the same as I do that they will never use anything else for headaches.



I have used Extra Strength Excedrin for over 40 years for moderate to extreme headaches. Since I could not use prescription painkillers, it was truly a lifesaver. In addition, it is very effective on other aches and pains such as muscle pain from overdoing and arthritis. I was very upset when it was taken off the market for a period of time.


Top Of The World

I just need to say thankyou!! for making such a wonderful product. I am old now and I think back of the times I needed something to bring my pain level down to tolerable so I could finish out my day. And Excedrin has taken care of me and still works just as it did when I was young. So I know I could almost say it would last for a lifetime. There sure isn't much of anything else that last that long. I do a lot of horse riding in the wilderness and pack my mules. I can hear the pills in the bottle as my mule steps so i get a big smile knowing that i did not forget my Excedrin

just me

I have used this product for many years

My boss had a bad headache. He asked me if I had another pain killer. I told him no but I had Excedrin. He took some and about 15 minutes later he came out of his office and said it was like a miracle. He thought he would have to go home but he feels great.


Headachefree without Exce

Excedrin Continues to Disappoint

Excedrin once was "the only thing that worked for my headaches", until I was forced by over a year's lack of product to find a substitute. Now that Execdrin is finally back on the shelves, it can ony be purchased as a huge, hard to swallow tablet (except for the overly expensive price per pill 24 count package). Excedrin has not done nearly enough to regain my consumer dollar.



This is the only product that works for me; I always make sure I have them on hand at home and in my purse.



I couldn't live without it!! It's the only headache medicine that hits the spot.

Donna 156


I use both the Excedrin Extra Strength and Excedrin Migraine. Love them both. They work fast and get me on my way. No other products work for me. My daughter and son use them also and they work fantastic. I don't leave home without it. I have highly recommended Excedrin to friends and family and now they won't use anything else. Best products on the market ! Thank you for making my life easier!!!!


Best ever product

I woke up this morning at 4:15 with a stabbing pain over my left eye. I knew if I didn't take excedrin immediately, I would have a migraine and throw up. I took it and within 30 minutes, the headache was completely gone. Thank you for a wonderful product .


Sadly Does Not Work Anymore Since Its Return

For my entire life, Excedrin was the ONLY thing that worked for my headaches & worked completely in 20 mins. I loved it so much I almost thought about buying stock in the company. Yet since it left the market for a couple of years and has now returned, it NEVER works for me! WHAT HAS CHANGED IN THE PRODUCT? WHAT WAS REMOVED? I am desperate as nothing works except the old formula Excedrin. I wish I could find out from the company why it was previously removed from the market, because the product has now changed and is not the same anymore.


best headache medicine

as a person with chronic pain on several medications for pain you think they would cover all the pains i have but they never work for my headaches i take 2 Excedrin at the first sign of a headache and no more headache and it also helps with some of my other aches i tried the store brands trying to save a dollar but nothing works better for my headaches than the original


Like Excedrin, but Hate the Caplet Form

Please bring back the Tablets!! Please bring back the Tablets!!


ex headache

works like a charm. Say goodbye finally to headaches and pretty good price. But I got my 1st bottle thru bzzagent. I can't really say anything about package it is same as anybody's else. Nothing fancy but not hard to open. Try this is you like more effectiveness in smaller tablet.



This is the only one that I buy!! It works within 20 minutes!!! I have a very low pain threshold and while I used to take 2, I found that I only need 1 for 99% of aches & pains!!! So, I get to save on the pills AND be pain free!!! I have them in every purse I use so I'm never without them. DON'T EVER PULL THIS OFF THE MARKET IF YOU CAN POSSIBLY HELP IT!! THANK YOU!!!!                                                                                                                                                                                                                                                                P.S. - My coworkers come to ME because I have EXCEDRIN!!! I've expanded your customer base!!! :)


Always works

This works for me everytime. I take 2 and my headache is gone in 10-15 min. My husband has chronic headaches and he takes only Excedrin as it is the only thing that knocks it out. I only wish your coupons could be added to my shopping card as I have no printer-but the product is awesome.


Extra Strenght

I love exccdrin is the only one that will help take away my headaches and migraines I can take and my headache goes aways within 15 mins dont know what I would do without the I buy at least 2 or 3 each month so if there is a recall I will not be without :)


Excedrin Extra Strength

Excedrin Extra Strength has been to my rescue many, many times. I love this product for fast relief from those nagging and irritating headaches. I have always used Excedrin Extra Strength for my headaches.



I hated it when Excedrin was temporarily off the market as absolutely nothing else would help my somewhat daily headaches. This is by far the best product available that consistently works for me.

Steve 222

The "ONE"

Excedrin is the only pain reliever I reach for, when I get a headache. It seems to be the only "one" that's works on me.


great features ...

Migraine and extra strength ... What is the difference ?

Learn the Science Behind Headaches